Menotrophin
CAS No.: 9002-68-0 (Gonadotrophin; Treatment of infertility)

Short Description:

Source: Extracted from the urine of healthy pregnant women
Function and use: For women, it can promote the maturation and ovulation of follicles, and maintain the function of the corpus luteum. For men, it can stimulate the development of Leydig cells, increase androgen secretion, promote testicular descent and the development of male secondary sexual characteristics. Combined with urinary gonadotropin, it can simulate the physiological peak of luteinizing hormone and induce ovulation. Clinically, chorionic gonadotropin is still the drug of choice for the treatment of menstrual disorders, anovulatory infertility, threatened abortion and habitual live birth, cryptorchidism, and male sexual dysfunction.

Menotrophin-Pharmacopoeia Standard: BP

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Product Detail

Product Tags

CAS No.: 61489-71-2
Complies with CP2020, USP43, BP2022

Specification

Menotrophin
Source		Menopausal woman urine
Process description		Menotrophin obtained from the urine of post-menopausal women, mainly contain follicle-stimulating hormone and luteinizing hormone.
Manufacturing requirements		This product should be extracted from healthy human urine. The production process should conform with the requirements of current version of Good Manufacturing Practice. It needs to undergo appropriate technological methods for virus safety control during the production process, so that any viruses such as hepatitis virus, human immunodeficiency virus, etc. can be removed or inactivated.
Pharnacopoeia standard		CP	BP
Character		An almost white to slightly yellow powder.Soluble in water.	An almost white or slightly yellow powder.Soluble in water
Identification		Causes enlargement of the ovaries of immature female rats and increases the weight of the seminal vesicles and prostate gland of immature male rats when administered as directed in the Assay.	Causes enlargement of the ovaries of immature female rats and increases the weight of the seminal vesicles and prostate gland of immature male rats when administered as directed in the Assay.
Test	ResidualSolvent(ethanol)	≤0.5%	≤0.5%
	Water	≤5%	Not more than 5.0%
	Abnormal toxicity	Conform with regulation	Conform with regulation
	Bacterial endotoxin	≤1EU/unit	Not more than 0.78 IU per IU of FSH.
Potency	FSH	Not less than 400IU/mg	Not less than 40 IU/mg
	LH/FSH	Approximately 1	Approximately 1
Microbial limit	TAMC	≤10³CFU/g	≤10³CFU/g
	TYMC	≤10²CFU/g	≤10²CFU/g
Virus	Hbs Ag	Should be negative（10mg/ml）	Should be negative（10mg/ml）
	HCV antibodies	_________	Should be negative
	HIV I+II	_________	Should be negative
Storage		Kept in an airtight, tamper-evident container and protected from light. Preserved in cold place.	Menotrophin should be kept in an airtight, tamper-evident container and protected from light.
Category		Gonadotropin drugs
Preparation		Menotrophin for injection