Enoxaparin Sodium
CAS No.: 679809-58-6 (Low molecular weight heparin)

Short Description:

Source: Extracted from porcine intestinal mucosa and degraded by β-elimination method.

Function and use: By inhibiting coagulation active factor X (FXa) and thrombin (FIIa), heparin pentose structure binds AT-III (antithrombin III), and exerts anticoagulant effect.
Enoxaparin sodium prevents venous thromboembolic disease (prevention of thrombosis in the veins), especially those associated with orthopaedic or general surgery; treats established deep vein thrombosis, with or without pulmonary embolism, clinical Symptoms are not severe, excluding pulmonary embolism requiring surgery or thrombolytic therapy; treatment of unstable angina pectoris and non-Q-wave myocardial infarction, in combination with aspirin; used in hemodialysis cardiopulmonary bypass to prevent thrombosis; treatment of acute ST segment Elevated myocardial infarction, combined with thrombolytics or concurrently with percutaneous coronary intervention (PCI).

Enoxaparin Sodium-Pharmacopoeia Standard: BP/EP


Product Detail

Product Tags


Enoxaparin Sodium
Source Intestinal mucosa of pigs
Quality standard






white or almost white; hygroscopic powder


freely soluble in water
identification The spectra exhibit maxima at 231±2nm The 13C NMR spectrum obtained is similar to that obtained with the appropriate specific Enoxaparin sodium CRS
The spectra are similar 15 -25 % bearing the 1,6-anhydro structure at the reducing end of their chain
Anti- Xa activity/ anti- IIa : 3.3-5.3 Anti- Xa activity/ anti- IIa : 3.3-5.3
Mw : 3800 -5000Da, M≤2000 : 12.0%-20.0%,                               M≥8000:NMT 18.0%, M2000-8000:68.0%-82.0% Mw : 3800 -5000Da, M≤2000 : 12.0%-20.0%,                               M≥8000:NMT 18.0%, M2000-8000:68.0%-82.0%
Meets the requirements for Sodium Content It complies with the test for sodium
Appearance of solution / clear;NMT: intensity 6
Specific Absorbance 14.0-20.0 (on the dried basis) 14.0-20.0 (on the dried basis),determined at 231nm
pH 6.2-7.7 6.2-7.7
Benzyl alcohol ≤ 0.1% ≤ 0.1%
Molar ratio of Sulfate carboxylate ≥ 1.8 ≥ 1.8
Nitrogen 1.8 %-2.5 % (on the dried basis) 1.5 %-2.5 % (on the dried basis)
Sodium 11.3% -13.5% (on the dried basis) 11.3% -13.5% (on the dried basis)
Loss on drying ≤ 10.0% ≤ 10.0%
Bacterial endotoxins <0.01EU/U <0.01EU/IU
Assay Anti- Xa activity 90-125 IU/mg (on the dried basis) 90-125 IU/mg (on the dried basis)
Anti- IIa activity 20-35 IU/mg (on the dried basis) 20-35 IU/mg (on the dried basis)

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