Nadroparin Calcium
CAS No.: 37270-89-6 (Low molecular weight heparin)

Short Description:

Source: extracted from pig intestinal mucosa, degraded by sodium nitrite, and obtained after calcium transfer.
Function and use: Nadroparin calcium is a low molecular weight heparin, which is depolymerized from unfractionated heparin with antithrombotic and anticoagulant effects; it has high anticoagulant factor Xa activity and low anticoagulant Factor IIa or antithrombin activity. In surgery, for the prevention of venous thromboembolic disease in situations of high or high risk of venous thrombosis; for the treatment of established deep vein thrombosis; in combination with aspirin for the acute treatment of unstable angina and non-Q-wave myocardial infarction ; Prevention of clot formation in extracorporeal circulation during hemodialysis.

Nadroparin Calcium-Pharmacopoeia Standard: BP/EP


Product Detail

Product Tags


Nadroparin calcium
Source Intestinal mucosa of pigs
Quality standard


characters Appearance white or almost white; hygroscopic powder
solubility freely soluble in water
identification The 13C NMR spectrum obtained is similar to that obtained with the appropriate specific nadroparin calcium CRS
Anti- Xa activity/ anti- IIa: 2.5-4.0
Mw: 3600 -5000Da, M≤2000: NMT 15%, M2000-8000: 75%-95%, M2000-4000: 35%-55%
It complies with the test for calcium
Appearance of solution NMT Intensity 5.
Ethanol ≤1.0%
pH 5.5-8.0
N-NO groups ≤ 0.25 ppm
Free sulfates ≤ 0.5%
Molar ratio of Sulfate carboxylate ≥1.8
Nitrogen 1.5 %-2.5 % (on the dried basis)
calcium 9.5% -11.5% (on the dried basis)
Loss on drying NMT 10.0%
Bacterial endotoxins <0.01EU/IU
Assay 95-130 IU/mg (on the dried basis)

Product Description

Nadroparin calcium is a new antithrombotic drug, which is obtained by depolymerizing heparin extracted from pig intestinal mucosa, with an average molecular weight of 4500 daltons. In vitro experiments showed that compared with heparin, low molecular weight heparin calcium had obvious anti Xa activity, but only slight anticoagulant activity. The risk of bleeding is far lower than heparin, and it has little effect on platelets. Subcutaneous injection has high bioavailability, long half-life and outstanding antithrombotic effect. Nadroparin calcium is a low molecular weight heparin preparation, which can make the ratio of anticoagulant factor Xa to IIa activity greater than 4, thus playing a strong anti thrombosis function and certain thrombolytic effect.

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